Identification of mutations of selected genes causing retinal degeneration in the domestic cat (Felis catus) – in silico analysis

Retinal degenerations are a series of genetically inherited diseases resulting in significant visual impairment and blindness. Among domestic cat breeds, there different courses associated with mutations CEP290, CRX, AIPL1 KIF3B genes. The aim this study was to design diagnostic tests identify the mutated alleles. primers for PCR restriction enzymes PCR-RFLP were designed detect Mutation nucleotide sequence encoding protein causes change structure, where monomer is formed instead homodimer. Interactions proteins other that play role proper functioning retina observed. occurring interactions between some these suggest possible link caused by genes proteins. In animal species, co-expression analyzed affecting retinal functions noted.